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One or more keywords matched the following properties of Gaiteri, Chris
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overview How do interaction networks at the levels of genes, proteins and cells support healthy cognitive function? How do semi-independent regulatory systems such as epigenetics, chromosome configuration, miRNA and transcription factors combine to support homeostasis? How do biological networks that operate on vastly different spatial and temporal scales, mesh together seamlessly? Are there collective network “signatures” of disease? How does the connectivity of a network condition its dynamics? How can we use network insights to identify key mediators of pathology? Chris Gaiteri, PhD, is interested in answering these questions, and in the context of Alzheimer’s disease uses several types of omics data to identify networks of molecules that are closely related to brain pathology. He has also used related approaches to study major depression and schizophrenia. Living in between computation and biology is a tricky place, so he’s always on the lookout for collaborators. Feel free to email and stop by and discuss how a network approach may benefit your research.
Person ID 349049
One or more keywords matched the following items that are connected to Gaiteri, Chris
Item TypeName
Concept Adaptor Proteins, Signal Transducing
Concept Longitudinal Studies
Concept Cerebral Amyloid Angiopathy
Concept Gene Expression Profiling
Concept Markov Chains
Concept Disease Models, Animal
Concept DNA Methylation
Concept Databases, Factual
Concept DNA-Binding Proteins
Concept Genetic Linkage
Concept Monte Carlo Method
Concept Genetic Association Studies
Concept alpha-Macroglobulins
Concept Cerebral Infarction
Concept Methylenetetrahydrofolate Reductase (NADPH2)
Concept Frontotemporal Lobar Degeneration
Concept Mutation
Concept Humans
Concept Hormones
Concept Sequence Analysis, RNA
Concept Epigenomics
Concept Benchmarking
Concept Organ Size
Concept Membrane Glycoproteins
Concept CpG Islands
Concept Gait
Concept Chicago
Concept Genetic Diseases, Inborn
Concept Gene Regulatory Networks
Concept Heterozygote
Concept Magnetic Resonance Imaging
Concept Foot Deformities
Concept Geriatric Assessment
Concept Chromatin Immunoprecipitation
Concept Molecular Biology
Concept Algorithms
Concept Insulin-Like Growth Factor Binding Protein 5
Concept Macrophages
Concept Epigenesis, Genetic
Concept Cluster Analysis
Concept Arthritis, Rheumatoid
Concept Sex Factors
Concept Neuroimaging
Concept Models, Genetic
Concept Alzheimer Disease
Concept Genome, Human
Concept Cognitive Reserve
Concept Genotype
Concept Transcriptome
Concept Plaque, Amyloid
Concept Mice, Inbred BALB C
Concept Depressive Disorder, Major
Concept Gyrus Cinguli
Concept Polymorphism, Single Nucleotide
Concept Cohort Studies
Concept Seasons
Concept Vitamin B 12
Concept Tuberous Sclerosis
Concept Quantitative Trait Loci
Concept Dementia
Concept High-Throughput Nucleotide Sequencing
Concept Case-Control Studies
Concept Reproducibility of Results
Concept Prospective Studies
Concept Cross-Sectional Studies
Concept Genome-Wide Association Study
Concept Multiple Sclerosis
Concept Proteomics
Concept Oligonucleotide Array Sequence Analysis
Concept Genetic Predisposition to Disease
Concept Genotyping Techniques
Concept Logistic Models
Concept Homozygote
Concept Cerebrovascular Disorders
Concept Mice
Concept Aging
Concept Genetic Variation
Concept Linear Models
Concept Hippocampus
Concept Models, Neurological
Concept Bayes Theorem
Concept Risk Factors
Concept Pyridoxal Phosphate
Concept Brain Infarction
Concept Base Sequence
Concept Alleles
Concept Follow-Up Studies
Concept Autopsy
Concept Amyloid beta-Peptides
Concept Immunohistochemistry
Concept Haplotypes
Concept Gene Expression Regulation
Concept Computational Biology
Concept Mice, Transgenic
Concept Exercise
Academic Article Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies.
Academic Article Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease.
Academic Article APOE e4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans.
Academic Article Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline.
Academic Article APOE e2e4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults.
Academic Article Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia.
Academic Article Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain.
Academic Article A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research.
Academic Article Multi-omic Directed Networks Describe Features of Gene Regulation in Aged Brains and Expand the Set of Genes Driving Cognitive Decline.
Academic Article Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts.
Academic Article APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults.
Academic Article The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia.
Academic Article Physical activity, common brain pathologies, and cognition in community-dwelling older adults.
Academic Article Supporting novel biomedical research via multilayer collaboration networks.
Academic Article Association of Cortical ?-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease.
Academic Article Cognition may link cortical IGFBP5 levels with motor function in older adults.
Academic Article Using Transcriptomic Hidden Variables to Infer Context-Specific Genotype Effects in the Brain.
Academic Article Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline.
Academic Article Genetic risk for Alzheimer's dementia predicts motor deficits through multi-omic systems in older adults.
Academic Article Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges.
Academic Article Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
Academic Article Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
Academic Article Deep learning decodes the principles of differential gene expression.
Academic Article Deconvolving the contributions of cell-type heterogeneity on cortical gene expression.
Academic Article Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice.
Academic Article A cortical immune network map identifies distinct microglial transcriptional programs associated with ?-amyloid and Tau pathologies.
Academic Article Cortical proteins may provide motor resilience in older adults.
Academic Article Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors.
Academic Article Cascading epigenomic analysis for identifying disease genes from the regulatory landscape of GWAS variants.
Academic Article Inferring protein expression changes from mRNA in Alzheimer's dementia using deep neural networks.
Academic Article Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Academic Article Dissecting the human leptomeninges at single-cell resolution.
Academic Article Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings.
Academic Article Robust, scalable, and informative clustering for diverse biological networks.
Academic Article Network Analytics Enabled by Generating a Pool of Network Variants from Noisy Data.
Academic Article A Molecular Basis of Human Brain Connectivity.
Academic Article Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer's disease.
Academic Article The molecular genetic landscape of human brain size variation.
Academic Article Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings.
Concept Cognitive Aging
Concept RNA Splicing Factors
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